Mistimed origin licensing and activation stabilize common fragile sites under tight DNA-replication checkpoint activation
Olivier Brison, Stefano Gnan, Dana Azar, Stéphane Koundrioukoff, Rodrigo Melendez-Garcia, Su-Jung Kim, Mélanie Schmidt, Sami El Hilali, Yan Jaszczyszyn, Anne-Marie Lachagès, Claude Thermes, Chun-Long Chen, Michelle Debatisse
Topics & Concepts
DNA replication factor CDT1Pre-replication complexOrigin recognition complexBiologyLicensing factorDNA replicationControl of chromosome duplicationMitosisDNA re-replicationGeneticsEukaryotic DNA replicationCell biologyG2-M DNA damage checkpointChromosomal fragile siteDNAChromosomeCell cycleCell cycle checkpointGeneDNA Repair MechanismsGenetics and Neurodevelopmental DisordersEpigenetics and DNA Methylation