Depletion of the diabetic gut microbiota resistance enhances stem cells therapy in type 1 diabetes mellitus
Wanqi Lv, Dana T. Graves, Linhai He, Yan Shi, Xuliang Deng, Yajun Zhao, Xian Dong, Ren Yi, Xinhua Liu, E. Xiao, Yi Zhang
Abstract
These results provide the rationale for a new approach to improve MSC therapy for T1DM by altering the gut microbiota.
Topics & Concepts
Gut floraInsulitisTransplantationDysbiosisAkkermansiaBiologyType 1 diabetesMicrobiologyStem cellDiabetes mellitusImmunologyInternal medicineMedicineEndocrinologyBacteriaCell biologyBacteroidesGeneticsGut microbiota and healthPancreatic function and diabetesDiabetes Management and Research