Multifaceted Nature of DNA Polymerase θ
Alexander A. Kruchinin, Аlena V. Makarova
Abstract
DNA polymerase θ belongs to the A family of DNA polymerases and plays a key role in DNA repair and damage tolerance, including double-strand break repair and DNA translesion synthesis. Pol θ is often overexpressed in cancer cells and promotes their resistance to chemotherapeutic agents. In this review, we discuss unique biochemical properties and structural features of Pol θ, its multiple roles in protection of genome stability and the potential of Pol θ as a target for cancer treatment.
Topics & Concepts
DNA polymerasePolymeraseDNA repairDNA damageBiologyDNADNA polymerase IIGeneticsCell biologyComputational biologyMolecular biologyGenePolymerase chain reactionReverse transcriptaseDNA Repair MechanismsCancer Genomics and DiagnosticsGenomics and Chromatin Dynamics