TNF-α-dependent neuronal necroptosis regulated in Alzheimer's disease by coordination of RIPK1-p62 complex with autophagic UVRAG
Chong Xu, Jialin Wu, Yiqun Wu, Zhichu Ren, Yuyuan Yao, Guobing Chen, Evandro Fei Fang, Ji Heon Noh, Yong Liu, Libin Wei, Xijing Chen, Jian Sima
Abstract
We identify a finely controlled regulation of neuronal necroptosis in AD by coordinated TNF-α signaling, RIPK1/3 activity and autophagy machinery. Strategies that could fine-tune necroptosis and autophagy may bring in promising therapeutics for AD.
Topics & Concepts
NecroptosisRIPK1AutophagyCell biologyProgrammed cell deathTumor necrosis factor alphaBiologySignal transductionChemistryApoptosisImmunologyBiochemistryAlzheimer's disease research and treatmentsAutophagy in Disease and TherapyCell death mechanisms and regulation