Management of hemophagocytic lymphohistiocytosis (HLH) associated with chimeric antigen receptor T-cell (CAR-T) therapy using anti-cytokine therapy: an illustrative case and review of the literature
Ajay Major, Jennifer Collins, Caroline Craney, Alisa K. Heitman, Emily Bauer, Elizabeth Zerante, Wendy Stock, Michael R. Bishop, Jagoda Jasielec
Abstract
Chimeric antigen receptor T-cell (CAR-T) therapy has significantly improved survival for adult patients with relapsed B-cell acute lymphoblastic leukemia (B-ALL). However, there are novel toxicitie...
Topics & Concepts
Hemophagocytic lymphohistiocytosisChimeric antigen receptorCytokine release syndromeMedicineImmunologyCAR T-cell therapyCell therapyImmunotherapyImmune systemCellBiologyInternal medicineDiseaseGeneticsCAR-T cell therapy researchAutoimmune and Inflammatory Disorders ResearchImmune Cell Function and Interaction