Disease Phenotypes and Mechanisms of iPSC-Derived Cardiomyocytes From Brugada Syndrome Patients With a Loss-of-Function SCN5A Mutation
Wener Li, Michael Stauske, Xiaojing Luo, Stefan Wagner, Meike Vollrath, Carola S. Mehnert, Mario Schubert, Lukas Cyganek, Simin Chen, Sayed-Mohammad Hasheminasab, Gerald Wulf, Ali El‐Armouche, Lars S. Maier, Gerd Hasenfuß, Kaomei Guan
Abstract
in BrS-CMs and alleviated the arrhythmic activity, suggesting their therapeutic potential for BrS patients.
Topics & Concepts
Brugada syndromeRepolarizationPhenotypeSudden cardiac deathInternal medicineMedicineInduced pluripotent stem cellSudden deathElectrophysiologyMutationCilostazolNerve conduction velocityConnexinCardiologyEndocrinologyCell biologyBiologyGap junctionIntracellularGeneticsGeneEmbryonic stem cellAspirinCardiac electrophysiology and arrhythmiasIon channel regulation and functionNeuroscience and Neural Engineering