Facile access to <i>gem</i>-difluorocyclopropanes <i>via</i> an <i>N</i>-heterocyclic carbene-catalyzed radical relay/cyclization strategy
Jibin Li, Liang Zheng, Yuzhi Ren, Jian Gao, Ding Du
Abstract
N -Heterocyclic carbene-catalyzed difluorocyclopropanation of alkenes with aldehydes and CF 2 Br 2 for a facile and efficacious synthesis of a new class of functionalized gem -difluorocyclopropanes bearing acyl groups was developed.
Topics & Concepts
CarbeneChemistryCatalysisMedicinal chemistryCombinatorial chemistryOrganic chemistryFluorine in Organic ChemistryCyclopropane Reaction MechanismsN-Heterocyclic Carbenes in Organic and Inorganic Chemistry