Uveal melanoma–associated mutations in PLCβ4 are constitutively activating and promote melanocyte proliferation and tumorigenesis
H. T. Phan, Nam Hoon Kim, Wenhui Wei, Gregory G. Tall, Alan V. Smrcka
Abstract
Mutant forms of a phospholipase C isoform mediate oncogenic signaling in uveal melanoma.
Topics & Concepts
MelanomaCancer researchMelanocyteEffectorCell growthCarcinogenesisMutationBiologyCell cultureGene isoformCancerMolecular biologyMedicineCell biologyGeneGeneticsOcular Oncology and TreatmentsRetinal Development and DisordersGlaucoma and retinal disorders