Membrane-destabilizing ionizable phospholipids for organ-selective mRNA delivery and CRISPR–Cas gene editing
Shuai Liu, Qiang Cheng, Tuo Wei, Xueliang Yu, Lindsay T. Johnson, Lukas Farbiak, Daniel J. Siegwart
Topics & Concepts
EndosomeGene deliveryGenome editingCas9CRISPRPhospholipidRNAMessenger RNACell biologyChemistryLiposomeRational designIn vivoSubgenomic mRNABiologyBiochemistryGeneMembraneGenetic enhancementCellGeneticsRNA Interference and Gene DeliveryCRISPR and Genetic EngineeringAdvanced biosensing and bioanalysis techniques