Leishmania major Strain-Dependent Macrophage Activation Contributes to Pathogenicity in the Absence of Lymphocytes
Jalal Alshaweesh, Risa Nakamura, Yuka Tanaka, Mizuki Hayashishita, Abu Musa, Mihoko Kikuchi, D.K. Inaoka, Shinjiro Hamano
Abstract
sp. and host immune protection. Previous works on mouse models of CL show the distinct pathogenicity of Leishmania major strains in the absence of lymphocytes. However, the mechanisms of this pathology remain uncovered. In the trial to understand the immunological process involved in lymphocyte-independent pathology, we have found a specific induction of macrophages by different L. major strains that affect their ability to mount innate responses leading to neutrophilic pathology when lymphocytes are ablated.
Topics & Concepts
Strain (injury)MacrophageLeishmaniaPathogenicityBiologyPhenotypeImmunologyVirologyMicrobiologyGeneticsParasite hostingGeneIn vitroWorld Wide WebComputer scienceAnatomyResearch on Leishmaniasis StudiesAutoimmune and Inflammatory Disorders ResearchTrypanosoma species research and implications