Design, synthesis, and biological evaluation of novel donepezil-tacrine hybrids as multi-functional agents with low neurotoxicity against Alzheimer’s disease
Ningwei Wang, Wenlong Jia, Junqin Wang, Zejun Yang, Yaoyang Liu, Yaoyang Liu, Dehua Huang, Xiaohan Mei, Xinxin Xiong, Jing Shi, Yadong Tang, Guang Chen, Donghua Di, Yunlei Hou, Yajing Liu, Yajing Liu
Topics & Concepts
TacrineChemistryAcetylcholinesteraseDonepezilNeuroprotectionNeurotoxicityPharmacologyButyrylcholinesteraseOxidative stressIC50CholinesteraseAchéViability assayAntioxidantReactive oxygen speciesToxicityBiochemistryApoptosisIn vitroEnzymeInternal medicineMedicineOrganic chemistryDiseaseDementiaCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsMedicinal Plants and Neuroprotection