Optimization of a Decatungstate-Catalyzed C(sp<sup>3</sup>)–H Alkylation Using a Continuous Oscillatory Millistructured Photoreactor
Zhenghui Wen, Apoorva Maheshwari, Carlo Sambiagio, Yuchao Deng, Gabriele Laudadio, Koen Van Aken, Yuhan Sun, Hannes P. L. Gemoets, Timothy Noël
Abstract
)-H alkylation protocol were carried out, and the results are presented here. The performance of the reactor was evaluated in correlation to several chemical and process parameters, including residence time, light intensity, catalyst loading, and substrate/reagent concentration. In comparison with previously reported batch and flow protocols, conditions were found that led to considerably higher productivity, achieving a throughput up to 36.7 mmol/h with a residence time of only 7.5 min.
Topics & Concepts
AlkylationCatalysisReagentResidence time (fluid dynamics)ChemistryPhotochemistrySubstrate (aquarium)PhotocatalysisContinuous reactorPhysical chemistryOrganic chemistryGeotechnical engineeringGeologyEngineeringOceanographyRadical Photochemical ReactionsOxidative Organic Chemistry ReactionsSulfur-Based Synthesis Techniques