Direct formation of 4,5-disubstituted carbazoles <i>via</i> regioselective dilithiation
Ian A. Pocock, Alya M. Alotaibi, Kesar Jagdev, Connor Prior, Gregory R. Burgess, Louise Male, Richard S. Grainger
Abstract
Carbazoles are widely exploited for their interesting photophysical and electronic properties, however bay (4,5-) functionalization is challenging, and previously inaccessible through carbazole C-H activation. We report a simple methodology which introduces a range of versatile 4,5-functionality, enabling the wider investigation of ring annulation and close proximity effects on carbazole properties.
Topics & Concepts
RegioselectivityChemistryCombinatorial chemistryStereochemistryOrganic chemistryCatalysisCatalytic C–H Functionalization MethodsFluorine in Organic ChemistryAsymmetric Synthesis and Catalysis