Proadrenomedullin N-Terminal 20 Peptides (PAMPs) Are Agonists of the Chemokine Scavenger Receptor ACKR3/CXCR7
Max Meyrath, Christie B. Palmer, Nathan Reynders, Alain Vanderplasschen, Markus Ollert, Michel Bouvier, Martyna Szpakowska, Andy Chevigné
Abstract
. Our results further extend the panel of endogenous ACKR3 ligands and broaden ACKR3 functions to a regulator of PAMP-12 availability for its primary receptor Mas-related G-protein-coupled receptor member X2 (MrgX2).
Topics & Concepts
Scavenger receptorReceptorAdrenomedullinCalcitonin gene-related peptideChemistryG protein-coupled receptorCalcitoninEndocrinologyBiochemistryBiologyNeuropeptideLipoproteinCholesterolNeuropeptides and Animal PhysiologyChemokine receptors and signalingReceptor Mechanisms and Signaling