Edible bird's nest inhibits the inflammation and regulates the immunological balance of lung injury mice by SO<sub>2</sub>
Hongliang Zeng, Yeye Jian, Yong Xie, Qunyan Fan, Qing Chang, Baodong Zheng, Yi Zhang
Abstract
Abstract The purpose was to investigate effect of edible bird's nest (EBN) on the immunological properties of mice with lung injury induced by sulfur dioxide (SO 2 ). In mice, SO 2 exposure caused symptoms that included a cough, tiredness, and weight loss. Administering EBN improved the immunological function of mice with lung injury in a dose‐dependent manner, leading to recovery of the lung tissue and increasing thymus and spleen indices. IL‐2 and IFN‐γ in the serum by Th1 cells in response to EBN played a leading role in cellular immune regulation. Moreover, a medium dose of EBN regulated the immune stress response, inhibited apoptosis of splenic lymphocytes, and promoted cellular immunity. EBN inhibited production of IL‐8 and MDA and upregulated mRNA expression of atrophin‐1 and cyclooxygenase‐2 in lung tissue. EBN attenuates the lung injury induced by SO 2 in mice through a mechanism that involves the inhibition of inflammation and regulation of immunological balance.