Acute Liver Failure in a Healthy Young Female With COVID‐19
Babak J. Orandi, Geling Li, Deepti Dhall, Prachi Bajpai, Upender Manne, Nitin Arora, Ailing Lu, Ana Carolina Coronado, Rachel Kassel, Swetha Pinninti, Cora E. Lewis, Christopher A. Chapleau, Jayme E. Locke, Luz Helena Gutierrez Sanchez
Abstract
Several well-described manifestations of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been reported. Among them, a transient elevation of liver enzymes is the typical presentation of coronavirus disease 2019 (COVID-19) liver-related injury. The mechanism of liver involvement is likely a combination of viral injury and immune-mediated inflammation. In contrast, acute liver failure in the setting of COVID-19 has rarely been reported. Herein, we report a case of pediatric acute liver failure in a previously healthy female adolescent infected with SARS-CoV-2 with biopsy evidence of replicating virus in hepatocytes, which has not been previously reported.