Dual Action of Acidic Microenvironment on the Enrichment of the Active Metabolite of Disulfiram in Tumor Tissues
Chongzhuang Tang, Xiaoyan Pang, Zitao Guo, Runcong Guo, Lu Liu, Xiaoyan Chen
Topics & Concepts
MetaboliteDisulfiramActive metaboliteChemistryTumor microenvironmentAction (physics)PharmacologyMechanism of actionMetabolismBiochemistryIn vitroBiologyTumor cellsCancer researchPhysicsQuantum mechanicsAlcohol Consumption and Health EffectsMetabolomics and Mass Spectrometry StudiesAutophagy in Disease and Therapy