Novel asymmetrical azines appending 1,3,4-thiadiazole sulfonamide: synthesis, molecular structure analyses, <i>in silico</i> ADME, and cytotoxic effect
Samir Bondock, Tallah Albarqi, Ibrahim A. Shaaban, Moaz M. Abdou
Abstract
Toward finding potential and novel anticancer agents, we designed and prepared novel differently substituted unsymmetrical azine-modified thiadiazole sulfonamide derivatives using the “combi-targeting approach”.
Topics & Concepts
ADMEIn silicoChemistrySulfonamideCombinatorial chemistryComputational chemistryStereochemistryBiochemistryIn vitroGeneSynthesis and Biological EvaluationSynthesis and Catalytic ReactionsPhenothiazines and Benzothiazines Synthesis and Activities