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The effect of alcohols as vehicles on the percutaneous absorption and skin retention of ibuprofen modified with <scp>l</scp>-valine alkyl esters

Paula Ossowicz‐Rupniewska, Joanna Klebeko, Ewa Janus, Anna Nowak, Wiktoria Duchnik, Łukasz Kucharski, Adam Klimowicz

2020RSC Advances42 citationsDOIOpen Access PDF

Abstract

The effect of various alcohols as vehicles on skin permeability was compared for unmodified ibuprofen (IBU) and ion pairs of ibuprofen with <sc>l</sc>-valine alkyl esters [ValOR][IBU], in which the alkyl chain R was changed from C1 to C8.

Topics & Concepts

ChemistryIbuprofenPermeationValineAlkylChromatographyIodideEthanolNuclear chemistryOrganic chemistryAmino acidBiochemistryMembraneMedicinePharmacologyAdvancements in Transdermal Drug DeliveryDermatology and Skin DiseasesContact Dermatitis and Allergies
The effect of alcohols as vehicles on the percutaneous absorption and skin retention of ibuprofen modified with <scp>l</scp>-valine alkyl esters | Litcius