Contributions of afferent and sympathetic renal nerves to cystogenesis and arterial pressure regulation in a preclinical model of autosomal recessive polycystic kidney disease
Madeline Gauthier, Melissa Dennis, Mark Morales, Heddwen L. Brooks, Christopher T. Banek
Abstract
This is the first study to dissect the contributions of renal sympathetic and afferent innervation in the PCK rat, a preclinical model of autosomal recessive polycystic kidney disease. We demonstrated that resting afferent renal nerve activity is greater in the PCK rat than noncystic controls and that basal afferent renal nerve activity is directly correlated with the extent of renal cystogenesis.
Topics & Concepts
DenervationPolycystic kidney diseaseKidneyMedicineEndocrinologyInternal medicineBlood pressureKidney diseaseAutosomal dominant polycystic kidney diseasePathologyGenetic and Kidney Cyst DiseasesOrgan Donation and TransplantationPediatric Urology and Nephrology Studies