Nigella sativa L. as immunomodulator and preventive effect on renal tissue damage of lupus mice induced by pristane
Zahrah Hikmah, Anang Endaryanto, I Dewa Gede Ugrasena, Anny Setijo Rahaju, Syaiful Arifin
Abstract
Introduction: L. is an herbal plant with Thimoquinone as the main therapeutic properties. This plants has been shown to cure for various diseases and affected the immune system by modulating cytokines and T regulatory cell (Treg) sot that able to prevent renal injury in several diseases, but studies on Systemic Lupus Erythematous are still rare. Objective: L. on renal tissue damage in Pristane induced Lupus (PIL)-mice model Methods: L.). At the end of 28 days of treatment, the mice were sacrificed to take a blood sample and kidney organ to evaluate the injury histopathologically. Results: L. group was the lowest and almost close to normal. Conclusion: L. may need to be considered for further research on its use as a complementary supplement in lupus patients.