Tumor-Infiltrating Lymphocyte Therapy for Melanoma and Other Solid Tumors: Looking Back, Yet Moving Forward
Alexander N. Shoushtari, Daniel J. Powell
Abstract
Lifileucel, the first solid tumor adoptive tumor infiltrating lymphocyte (TIL) therapy product to receive regulatory approval in advanced melanoma, represents a critical achievement in the pursuit of improving outcomes using cellular therapies in patients with solid tumors. This review traces the development of adoptive TIL therapy from the initial human studies in melanoma, through recent advances in studies of other solid tumors, and previews ongoing and future areas for preclinical and clinical advances to improve upon this novel therapeutic strategy.
Topics & Concepts
MelanomaTumor-infiltrating lymphocytesMedicineSolid tumorCancer researchPathologyImmunologyImmunotherapyInternal medicineImmune systemCancerCAR-T cell therapy researchImmunotherapy and Immune ResponsesImmune Cell Function and Interaction