Targeting mPGES-1 by a Combinatorial Approach: Identification of the Aminobenzothiazole Scaffold to Suppress PGE<sub>2</sub> Levels
Maria Giovanna Chini, Assunta Giordano, Marianna Potenza, Stefania Terracciano, Katrin Fischer, Maria Carmela Vaccaro, Ester Colarusso, Ines Bruno, Raffaele Riccio, Andreas Koeberle, Oliver Werz, Giuseppe Bifulco
Abstract
= 1.4 ± 0.2, 0.7 ± 0.1, and 1.7 ± 0.2 μM, respectively), and all are endowed with antitumoral properties against A549 human cancer cell lines at micromolar concentrations (28.5 ± 1.1, 18.1 ± 0.8, and 19.2 ± 1.3 μM, respectively).
Topics & Concepts
ScaffoldVirtual screeningProstaglandin E2IC50ChemistryProstaglandin EEnzymeIdentification (biology)ProstaglandinCombinatorial chemistryCell cultureComputational biologyBiochemistryComputer scienceIn vitroBiologyMedicineDrug discoveryInternal medicineDatabaseBotanyGeneticsInflammatory mediators and NSAID effectsPeptidase Inhibition and AnalysisEstrogen and related hormone effects