Design, synthesis, and antitumor activity evaluation of potent fourth-generation EGFR inhibitors for treatment of Osimertinib resistant non-small cell lung cancer (NSCLC)
Yuchen Zhang, Lexian Tong, Fangjie Yan, Ping Huang, Cheng‐Liang Zhu, Chenghao Pan
Topics & Concepts
T790MOsimertinibEpidermal growth factor receptorChemistryEGFR inhibitorsPharmacologyLung cancerCancer researchCancerIC50In vivoIn vitroMedicineReceptorOncologyErlotinibInternal medicineBiologyGefitinibBiochemistryBiotechnologyLung Cancer Treatments and MutationsCancer therapeutics and mechanismsColorectal Cancer Treatments and Studies