Ganglioside GM1 produces stable, short, and cytotoxic Aβ <sub>40</sub> protofibrils
Manjeet Kumar, Magdalena I. Ivanova, Ayyalusamy Ramamoorthy
Abstract
Monosialoganglioside GM1-bound amyloid β-peptides have been found in patients’ brains exhibiting early pathological changes of Alzheimer's disease.
Topics & Concepts
Cytotoxic T cellChemistryGangliosidePeptideBiophysicsAmyloid (mycology)Protein aggregationBiochemistryBiologyIn vitroInorganic chemistryAlzheimer's disease research and treatmentsGlycosylation and Glycoproteins ResearchSupramolecular Self-Assembly in Materials