From development to cancer - an ever-increasing role of AGR2.
Daria Jach, Yuzhu Cheng, Filip Prica, Laurent Dumartin, Tatjana Crnogorac‐Jurcevic
Abstract
, where it plays an important function in embryonic development. Akin to several other developmental genes, it is also frequently deregulated in cancer, where it plays a decisive role in tumor initiation, progression and metastasis. In this review, we have summarized currently known AGR2 functions, its expression and function in embryonic and cancer development, as well as its potential as a candidate tumor biomarker and promising new target for cancer immunotherapy.
Topics & Concepts
XenopusBiologyMetastasisCancerEndoplasmic reticulumCell biologySignal transductionFunction (biology)Embryonic stem cellCancer researchGeneGeneticsEndoplasmic Reticulum Stress and DiseaseApelin-related biomedical researchNeuroblastoma Research and Treatments