Moonlighting glyceraldehyde-3-phosphate dehydrogenase: posttranslational modification, protein and nucleic acid interactions in normal cells and in human pathology
Michael A. Sirover
Abstract
Moonlighting glyceraldehyde-3-phosphate dehydrogenase (GAPDH) exhibits multiple functions separate and distinct from its historic role in energy production. Further, it exhibits dynamic changes in its subcellular localization which is an a priori requirement for its multiple activities. Separately, moonlighting GAPDH may function in the pathology of human disease, involved in tumorigenesis, diabetes, and age-related neurodegenerative disorders. It is suggested that moonlighting GAPDH function may be related to specific modifications of its protein structure as well as the formation of GAPDH protein: protein or GAPDH protein: nucleic acid complexes.
Topics & Concepts
Glyceraldehyde 3-phosphate dehydrogenaseNucleic acidBiochemistryBiologyDehydrogenaseGlyceraldehydeFunction (biology)EnzymeCell biologyMolecular Biology Techniques and ApplicationsRNA Interference and Gene DeliveryRNA and protein synthesis mechanisms