Regulatory T Cells Support Breast Cancer Progression by Opposing IFN-γ-Dependent Functional Reprogramming of Myeloid Cells
Nicholas M. Clark, Leandro Marcelo Martinez, Steven Murdock, James T. DeLigio, Amy L. Olex, Comfort Effi, Mikhail G. Dozmorov, Paula D. Bos
Abstract
inflammatory monocytes, which primarily differentiate into tumor-associated macrophages (TAMs), and lead to reprogramming of their function in an IFN-γ-dependent manner. Furthermore, transcriptomic signatures from murine TAMs in Treg cell-ablated conditions correlate with increased overall survival in human breast cancer. Our studies highlight the strong myeloid dependency of breast cancer and provide the basis for the development of therapeutic strategies based on manipulation of the IFN-γ signaling pathway in monocytes.
Topics & Concepts
ReprogrammingCancer researchAdoptive cell transferMyeloidBreast cancerBiologyImmunologyTumor microenvironmentCancerCellImmune systemT cellGeneticsImmune cells in cancerImmunotherapy and Immune ResponsesImmune Cell Function and Interaction