Hydroxyurea reduces infections in children with sickle cell anemia in Uganda
Ruth Namazzi, Caitlin Bond, Andrea L. Conroy, Dibyadyuti Datta, Abner Tagoola, Michael Goings, Jeong Hoon Jang, Russell E. Ware, Robert O. Opoka, Chandy C. John
Abstract
ABSTRACT: After starting hydroxyurea treatment, Ugandan children with sickle cell anemia had 60% fewer severe or invasive infections, including malaria, bacteremia, respiratory tract infections, and gastroenteritis, than before starting hydroxyurea treatment (incidence rate ratio, 0.40 [95% confidence interval, 0.29-0.54]; P < .001).
Topics & Concepts
Sickle cell anemiaMedicineAnemiaMalariaPediatricsImmunologyInternal medicineDiseaseHemoglobinopathies and Related DisordersIron Metabolism and DisordersMyeloproliferative Neoplasms: Diagnosis and Treatment