A mitochondrial cytidine deaminase is responsible for C to U editing of tRNA<sup>Trp</sup> to decode the UGA codon in <i>Trypanosoma brucei</i>
Zdeněk Paris, Michaela Svobodová, Ambar Kachale, Eva Horáková, Anna Nenarokova, Julius Lukeš
Abstract
. The ablation of TbmCDAT led to the downregulation of mitochondrial protein synthesis, supporting its role in decoding the UGA tryptophan codon.
Topics & Concepts
BiologyTransfer RNACytidineCytidine deaminaseRNA editingGeneticsGenetic codeTrypanosoma bruceiTranslation (biology)MitochondrionStop codonBiochemistryGeneMolecular biologyRNAEnzymeMessenger RNATrypanosoma species research and implicationsRNA and protein synthesis mechanismsInsect symbiosis and bacterial influences