Base-Promoted Tandem S<sub>N</sub>Ar/Boulton–Katritzky Rearrangement: Access to [1,2,4]Triazolo[1,5-<i>a</i>]pyridines
Zihao Li, Kongxi Qiu, Xiao Yang, Wei Zhou, Qian Cai
Abstract
A base-promoted tandem SNAr/Boulton–Katritzky rearrangement is developed. It offers a simple and straightforward method for the formation of functionalized [1,2,4]triazolo[1,5-a]pyridines from 1,2,4-oxadiazol-3-amines or 3-aminoisoxazoles with 2-fluoropyridines.
Topics & Concepts
ChemistryTandemNucleophilic aromatic substitutionBase (topology)Smiles rearrangementComputational chemistryCombinatorial chemistryStereochemistryMedicinal chemistryNucleophilic substitutionMaterials scienceMathematicsComposite materialMathematical analysisSynthesis and Biological EvaluationClick Chemistry and ApplicationsSynthesis and Reactivity of Heterocycles