The cross-kingdom interaction between Helicobacter pylori and Candida albicans
Xi Chen, Xuedong Zhou, Binyou Liao, Yujie Zhou, Lei Cheng, Biao Ren
Abstract
Helicobacter pylori is a gram-negative microaerophilic bacterium. The infection of H. pylori can increase the risk of gastric cancer which is the second leading cause of cancer death worldwide The World Health Organization's International Agency for Research on Cancer (IARC) has classified H. pylori as a type I (definite) carcinogen since 1994. H. pylori infection is a global health problem. In developed countries, its infection rate is 20% to 50%, while in developing countries, the infection rate of middle-aged people has reached 80% The fecaloral and the oral-oral routes are considered as the main transmission routes of H. pylori Nevertheless, only H. pylori genes have been detected in saliva and dental plaques, but culturable H. pylori has not been isolated yet in large quantities