Killer immunoglobulin-like receptors/human leukocyte antigen class-I, a crucial immune pathway in cancer
Yi Xu, Lei Wang, Wei Li, Bin Chen, Yu Liu, Hao Wang, Sha Zhao, Lingyun Ye, Yayi He, Caicun Zhou
Abstract
Natural killer cells (NK cells) play a crucial role in tumor immunity. The function of the NK cells is regulated by various receptors expressed on the surface. Among them, the killer immunoglobulin-like receptor (KIR) is one of the most important. The ligand of KIR is major histocompatibility complex class-I (MHC class-I), which is also called human leukocyte antigen class-I (HLA class-I). The combination of HLA class-I and inhibitory KIRs could inhibit NK cells and induce autoimmune tolerance. Inhibitory KIRs were highly expressed on malignant tumor patients, which were related to poor prognosis. KIR/HLA class-I pathway affected the clinical outcomes of cancer through several mechanisms, and inhibitory KIRs could be an ideal target of immunotherapy strategy.