miR-424/322 protects against abdominal aortic aneurysm formation by modulating the Smad2/3/runt-related transcription factor 2 axis
Hsiao‐Ya Tsai, Jen‐Chun Wang, Yu‐Juei Hsu, Yi‐Lin Chiu, Chih‐Yuan Lin, Cheng‐Yo Lu, Shih‐Hung Tsai
Abstract
. Compared to their littermates, miR-322 KO mice were susceptible to AngII-induced AAA, whereas the silencing of RUNX2 and the administration of exogenous miR-322 mimics ameliorated the AngII-induced AAA in ApoE KO mice. Overall, we established the roles of the Smad/RUNX2/miR-424/322 axis in AAA pathogenesis. We demonstrated the therapeutic potentials of miR-424/322 mimics and RUNX2 inhibitor for AAA progression.
Topics & Concepts
Abdominal aortic aneurysmTranscription factorCell biologyBiologyAnatomyCancer researchInternal medicineAneurysmMedicineGeneRadiologyGeneticsAortic aneurysm repair treatmentsAortic Disease and Treatment ApproachesInfectious Aortic and Vascular Conditions