Metalation: nature’s challenge in bioinorganic chemistry
Nigel J. Robinson, Arthur Glasfeld
Abstract
The association of proteins with metals, metalation, is challenging because the tightest binding metals are rarely the correct ones. Inside cells, correct metalation is enabled by controlled bioavailability plus extra mechanisms for tricky combinations such as iron and manganese.
Topics & Concepts
MetalationBioinorganic chemistryChemistryManganeseBioavailabilityCombinatorial chemistryBiochemistryStereochemistryOrganic chemistryPharmacologyBiologyTrace Elements in HealthMetal complexes synthesis and propertiesMetalloenzymes and iron-sulfur proteins