Exerkine apelin reverses obesity-associated placental dysfunction by accelerating mitochondrial biogenesis in mice
Song Ah Chae, Jun Seok Son, Liang Zhao, Yao Gao, Xiangdong Liu, Jeanene M. de Avila, Mei‐Jun Zhu, Min Du
Abstract
Maternal exercise prevents metabolic disorders of mothers and offspring induced by high-fat diet. Exercise intervention enhances PRDM16 activation, oxidative metabolism, and vascularization of placenta, which are inhibited due to maternal obesity. Similar to maternal exercise, apelin administration improves placental function of obese dams.
Topics & Concepts
ApelinMitochondrial biogenesisBiogenesisObesityInternal medicineMitochondrionEndocrinologyMedicineBiologyCell biologyGeneticsGeneReceptorApelin-related biomedical researchLipid metabolism and disordersAdipose Tissue and Metabolism