Prevalence of pharmacogenomic variants in 100 pharmacogenes among Southeast Asian populations under the collaboration of the Southeast Asian Pharmacogenomics Research Network (SEAPharm)
Chakkaphan Runcharoen, Koya Fukunaga, Insee Sensorn, Nareenart Iemwimangsa, Sommon Klumsathian, Hang Thi Tong, Nam S. Vo, Ly Le, Tin Maung Hlaing, Myo Thant, Shamsul Mohd Zain, Zahurin Mohamed, Yuh Fen Pung, Francis R Capule, Jose B. Nevado, Catherine Lynn T. Silao, Zeina N. Al-Mahayri, Bassam R. Ali, Rika Yuliwulandari, Kinasih Prayuni, Hilyatuz Zahroh, Dzul Azri Mohamed Noor, Phonepadith Xangsayarath, Dalouny Xayavong, Sengchanh Kounnavong, Somphou Sayasone, Zoe Kordou, Ioannis Liopetas, Athina Tsikrika, Evangelia Eirini Tsermpini, Maria Koromina, Christina Mitropoulou, George P. Patrinos, Aumpika Kesornsit, Angkana Charoenyingwattana, Sukanya Wattanapokayakit, Surakameth Mahasirimongkol, Taisei Mushiroda, Wasun Chantratita
Abstract
Pharmacogenomics can enhance the outcome of treatment by adopting pharmacogenomic testing to maximize drug efficacy and lower the risk of serious adverse events. Next-generation sequencing (NGS) is a cost-effective technology for genotyping several pharmacogenomic loci at once, thereby increasing publicly available data. A panel of 100 pharmacogenes among Southeast Asian (SEA) populations was resequenced using the NGS platform under the collaboration of the Southeast Asian Pharmacogenomics Research Network (SEAPharm). Here, we present the frequencies of pharmacogenomic variants and the comparison of these pharmacogenomic variants among different SEA populations and other populations used as controls. We investigated the different types of pharmacogenomic variants, especially those that may have a functional impact. Our results provide substantial genetic variations at 100 pharmacogenomic loci among SEA populations that may contribute to interpopulation variability in drug response phenotypes. Correspondingly, this study provides basic information for further pharmacogenomic investigations in SEA populations.