Clinically translatable gold nanozymes with broad spectrum antioxidant and anti-inflammatory activity for alleviating acute kidney injury
Dongyang Zhang, Tianhui Tu, Muhammad Rizwan Younis, Kathy S. Zhu, Hengke Liu, Shan Lei, Junle Qu, Jing Lin, Peng Huang
Abstract
Owing to the synergistic anti-inflammatory/antioxidative effects, and enhanced bioavailability and renal accumulation/retention, Au NCs-NAC displayed far superior therapeutic performance than NAC alone. This work will facilitate the development of high-performance antioxidative nanoplatforms, as well as overcome the clinical limitations of small molecular drugs for AKI treatment and other inflammatory diseases.
Topics & Concepts
Acute kidney injuryPharmacologyInflammationLipopolysaccharideKidneyIn vivoOxidative stressChemistryToxicityAntioxidantMedicineRenal functionBioavailabilityAcetylcysteineImmunologyInternal medicineBiochemistryBiologyBiotechnologyAdvanced Nanomaterials in CatalysisAcute Kidney Injury ResearchNeurological Complications and Syndromes