Superinfection Exclusion of Alphaherpesviruses Interferes with Virion Trafficking
James P. Cwick, Jonathan E Owen, Irina Kochetkova, Kyle S. Hain, Nick Van Horssen, Matthew P. Taylor
Abstract
Most viruses utilize a form of superinfection exclusion to conserve resources and control population dynamics. gD-dependent superinfection exclusion in alphaherpesviruses is well documented. However, the undercharacterized gD-independent SIE provides new insight into how alphaherpesviruses limit sequential infection. The observations described here demonstrate that gD-independent SIE differs between PRV and HSV-1. Comparing these differences provides new insights into the underlying mechanisms of SIE implemented by two related viruses.
Topics & Concepts
SuperinfectionBiologyEvolutionary biologyVirologyVirusHerpesvirus Infections and TreatmentsCytomegalovirus and herpesvirus researchParvovirus B19 Infection Studies