Synthesis of Thiazoles and Isothiazoles via Three-Component Reaction of Enaminoesters, Sulfur, and Bromodifluoroacetamides/Esters
Xingxing Ma, Xiaoxia Yu, Hua Huang, Yao Zhou, Qiuling Song
Abstract
A three-component strategy for the synthesis of thiazoles and isothiazoles has been developed by employing enaminoesters, fluorodibromoiamides/ester, and sulfur. The thiazoles and isothiazoles were formed via two C-F bond cleavages along with the formation of new C-S, C-N, and N-S bonds. The strategy provides high selectivity for the synthesis of thiazoles/isothiazoles, which have vital applications in drug discovery and development.
Topics & Concepts
ChemistrySulfurComponent (thermodynamics)Combinatorial chemistrySelectivityReaction conditionsOrganic chemistryCatalysisPhysicsThermodynamicsSulfur-Based Synthesis TechniquesClick Chemistry and ApplicationsSynthesis and Catalytic Reactions