Iron deficient diets modify the gut microbiome and reduce the severity of enteric infection in a mouse model of S. Typhimurium-induced enterocolitis
James Ippolito, Brian D. Piccolo, Michael S. Robeson, David E Barney, Jamel Ali, Prashant Singh, Stephen R. Hennigar
Abstract
. Unabsorbed iron in the lower intestine modifies the gut microbiome and promotes a more severe enteropathy. These findings could suggest the need for alternative iron supplementation strategies in areas where enteric infection are common.
Topics & Concepts
CecumWeanlingMicrobiologyHepcidinGastrointestinal tractMicrobiomeSalmonellaSmall intestineBiologyEnteropathySalmonella entericaGut floraInternal medicineImmunologyImmune systemFecesPhysiologyMedicineInflammationBacteriaGeneticsBioinformaticsDiseaseIron Metabolism and DisordersChild Nutrition and Water AccessTrace Elements in Health