Mechanobiological modulation of blood–brain barrier permeability by laser stimulation of endothelial-targeted nanoparticles
Xiaoqing Li, Qi Cai, Blake A. Wilson, Hanwen Fan, Harsh Dave, Monica Giannotta, Robert Bachoo, Zhenpeng Qin
Abstract
influx with contributions from mechanosensitive ion channels (TRPV4, Piezo1). We provide insight into how the excitation of tight junction protein (JAM-A)-targeted and endothelial (glycocalyx)-targeted AuNPs leads to similar mechanobiological modulation of BBB permeability while targeting the glycocalyx significantly improves the nanoparticle accumulation in the brain. The results will be critical for guiding the future development of this technology for brain disease treatment.
Topics & Concepts
Blood–brain barrierPermeability (electromagnetism)StimulationMaterials scienceBiophysicsLaserNanoparticleColloidal goldModulation (music)Vascular permeabilityNanotechnologyChemistryNeuroscienceMedicinePathologyBiologyCentral nervous systemOpticsBiochemistryPhysicsMembranePhilosophyAestheticsPhotoacoustic and Ultrasonic ImagingConnexins and lens biologyLaser-Ablation Synthesis of Nanoparticles