<i>Cis,cis,trans</i>-[Pt<sup>IV</sup>Cl<sub>2</sub>(NH<sub>3</sub>)<sub>2</sub>(perillato)<sub>2</sub>], a dual-action prodrug with excellent cytotoxic and antimetastatic activity
Mauro Ravera, Elisabetta Gabano, Ilaria Zanellato, Beatrice Rangone, Elena Perin, Béatrice Ferrari, Maria Grazia Bottone, Domenico Osella
Abstract
] exhibited excellent antiproliferative and antimetastatic activity on A-549 lung tumor cells at nanomolar concentrations. A number of in vitro biological tests were performed to decipher some aspects of its mechanism of action, including transwell migration and invasion as well as wound healing assay.
Topics & Concepts
ProdrugChemistryCytotoxic T cellAction (physics)StereochemistryMedicinal chemistryPhysicsBiochemistryIn vitroQuantum mechanicsMetal complexes synthesis and propertiesOrganometallic Complex Synthesis and CatalysisMagnetism in coordination complexes