Caspase-3-dependent peritubular capillary dysfunction is pivotal for the transition from acute to chronic kidney disease after acute ischemia-reperfusion injury
Shanshan Lan, Bing Yang, Francis Migneault, Julie Turgeon, Maude Bourgault, Mélanie Dieudé, Héloïse Cardinal, Michael J. Hickey, Natacha Patey, Marie‐Josée Hébert
Abstract
Our findings demonstrate the pivotal importance of caspase-3 in regulating renal microvascular dysfunction, fibrogenesis, and long-term renal impairment after acute kidney injury induced by ischemia-reperfusion injury. Furthermore, this study establishes the predominant role of peritubular capillary integrity as a major contributor to progressive renal dysfunction after ischemia-reperfusion injury.
Topics & Concepts
Peritubular capillariesAcute kidney injuryRenal functionMedicineKidney diseaseKidneyIschemiaPathologyInternal medicineReperfusion injuryEndocrinologyAcute Kidney Injury ResearchChronic Kidney Disease and DiabetesMuscle and Compartmental Disorders