Palladium-Catalyzed Aminations in Flow ... <i>on Water</i>
Madison J. Wong, Erfan Oftadeh, John M. Saunders, Alex B. Wood, Bruce H. Lipshutz
Abstract
Aminations can be efficiently run, under plug flow conditions on water, catalyzed by low levels of a recyclable palladium precatalyst. General protocols to couple amines, both aryl and aliphatic, with aryl/heteroaryl bromides have been developed. Further highlights include “on water” conditions, short reaction times, recycling of the reaction medium, low levels of residual Pd in the isolated products, and low E factors as a green metric, all of these features showcasing this alternative to amination reactions typically run in batch mode.
Topics & Concepts
AminationPalladiumCatalysisArylChemistryTonneCombinatorial chemistryOrganic chemistryAlkylInnovative Microfluidic and Catalytic Techniques InnovationCatalytic Cross-Coupling ReactionsAsymmetric Hydrogenation and Catalysis