Efficacy of Cerebrospinal Fluid Beta- <scp>d</scp> -Glucan Diagnostic Testing for Fungal Meningitis: a Systematic Review
Christian Davis, L. Joseph Wheat, Thein Myint, David R. Boulware, Nathan C. Bahr
Abstract
Several case reports and cohort studies have examined the use of (1,3)-beta- d -glucan measurement with cerebrospinal fluid to diagnose fungal meningitis. This systematic review aims to characterize the evidence regarding cerebrospinal fluid (1,3)-beta- d -glucan measurement to detect fungal meningitis. We searched PubMed for (1,3)-beta- d -glucan and each of several distinct fungi, cerebrospinal fluid, and meningitis. Summary data including diagnostic performance (where applicable) were recorded.
Topics & Concepts
Cerebrospinal fluidMeningitisMedicineBeta-glucanMicrobiologyGlucanPathologyChemistryBiologyPediatricsBiochemistryAntifungal resistance and susceptibilityFungal Infections and StudiesMyasthenia Gravis and Thymoma