IL-9 signaling redirects CAR T cell fate toward CD8+ memory and CD4+ cycling states, enhancing antitumor efficacy
Sofía Castelli, Wesley V. Wilson, Uğur Uslu, Amanda Finck, Philipp C. Rommel, Charles‐Antoine Assenmacher, Sebastian J Atoche, Mikko Siurala, M. Ángela Aznar, Regina M. Young, Carl H. June
Topics & Concepts
Chimeric antigen receptorBiologyT cellCell biologyCancer researchSTAT4Transcription factorCell fate determinationSignal transductionEffectorIL-2 receptorCellAntigenReceptorImmunotherapyCD8Cytotoxic T cellJAK-STAT signaling pathwayInterleukin 2RNAPhenotypeCo-receptorImmunologyMemory T cellTumor microenvironmentCellular differentiationCAR-T cell therapy researchImmunotherapy and Immune ResponsesCancer Immunotherapy and Biomarkers