Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion
Elizabeth Murray, Shinelle Menezes, Jack C. Henry, J.L.D. Williams, Lorena Alba‐Castellón, Priththivika Baskaran, Ivan Quétier, Ami V. Desai, J. Marshall, Ian Rosewell, Marianthi Tatari, Vinothini Rajeeve, Faraz Khan, Jun Wang, Panoraia Kotantaki, Eleanor J. Tyler, Namrata Singh, Claire S. Reader, Edward Carter, Kairbaan Hodivala‐Dilke, Richard Grose, Hemant M. Kocher, Núria Gavara, Oliver M.T. Pearce, Pedro R. Cutillas, John F. Marshall, Angus J.M. Cameron
Abstract
matrisome signature predicts poor outcome in pancreatic and other solid human cancers. Our data indicate that suppressing PSC myofibroblast function can limit important stromal tumor-suppressive mechanisms, while promoting a switch to a cancer-supporting CAF phenotype.
Topics & Concepts
MyofibroblastHepatic stellate cellPancreatic cancerCancer researchStromal cellBiologyCancer-Associated FibroblastsCell biologyTumor microenvironmentPancreatic tumorPathologyCancerFibrosisMedicineEndocrinologyTumor cellsGeneticsPancreatic and Hepatic Oncology ResearchPancreatic function and diabetesPhagocytosis and Immune Regulation