Adjunctive Rifampicin Increases Antibiotic Efficacy in Group A Streptococcal Tissue Infection Models
Helena Bergsten, Laura M. Palma Medina, Marina S. Morgan, Kirsten Moll, Dag Harald Skutlaberg, Steinar Skrede, Takeaki Wajima, Mattias Svensson, Anna Norrby‐Teglund
Abstract
Biofilm has recently been highlighted as a complicating feature of necrotizing soft tissue infections (NSTI) caused by Streptococcus pyogenes (i.e., group A Streptococcus [GAS]) contributing to a persistence of bacteria in tissue despite prolonged antibiotic therapy. Here, we assessed the standard treatment of benzylpenicillin and clindamycin with or without rifampin in a tissue-like setting.
Topics & Concepts
AntibioticsMicrobiologyClindamycinStreptococcus pyogenesRifampicinStreptococcusBiofilmAdjunctive treatmentMedicineBiologyBacteriaInternal medicineStaphylococcus aureusGeneticsStreptococcal Infections and TreatmentsBacterial Identification and Susceptibility TestingAntimicrobial Resistance in Staphylococcus