Myeloid Nrf2 deficiency aggravates non-alcoholic steatohepatitis progression by regulating YAP-mediated NLRP3 inflammasome signaling
Peng Wang, Ming Ni, Yizhu Tian, Hao Wang, Jiannan Qiu, Wenhua You, Wei Song, Yong Shi, Jinren Zhou, Feng Cheng, Jianhua Rao, Ling Lü
Abstract
Overexpression Nrf2 in liver macrophages effectively alleviated steatohepatitis in wild-type mice fed with an HFD . Our data support that by modulating YAP-mediated NLRP3 inflammasome activity, macrophage Nrf2 slows down NASH progression.
Topics & Concepts
InflammasomeSteatohepatitisSteatosisLiver injuryInflammationIn vivoFatty liverChemistryPathogenesisCell biologyActivator (genetics)Cancer researchImmunologyBiologyEndocrinologyInternal medicineMedicineBiochemistryReceptorBiotechnologyDiseaseLiver Disease Diagnosis and TreatmentInflammasome and immune disordersDiet, Metabolism, and Disease